Platelet polymorphism <i>rs5918T &gt; C</i> in the integrin B3 gene modulates comorbidities in patients with psoriasis

Psoriasis Vulgaris is a complex multifactorial dermatological disease, with various genetic and environmental factors implicated in the onset progression of disease comorbidities. Cardiovascular (CVD) metabolic syndrome are essential psoriasis comorbidities that suggest potential hypercoagulable background disease. To better understand link between psoriasis, hypercoagulation comorbidities, we investigated prothrombotic polymorphism rs5918T > C integrin B3 (ITGB3) 102 patients diagnosed 97 healthy controls, all Caucasian. The patients, carriers polymorphism, were compared non-carriers for risk related to CV Our results revealed incidence ITGB3rs5918(C) allele carriage was only slightly increased psoriatic controls (20.6% vs 18.6%), showed an factors. Dyslipidemia, high triglycerides (42.9% 27.5%), cholesterol (66.7% 45.5%) low High Density Lipoprotein (HDL) (47.6% 32.8%) significantly more prevalent (p = .019) among rs5918(C) non-carriers. higher (52.4%) (20.5%) within patient group .014), whereas CVD but non-significantly. associated dyslipidaemias non-significant prevalence However, frequency this similar controls.